Salentra Biosciences Enables Innovative
Diabetes Research with SCIslets
Leveraging both engineering and developmental biology principles Salentra has developed proprietary technology for the differentiation of human pluripotent stem cells into functionally mature Islets. Our differentiation pipeline is scalable, capable of generating billions of cells in a single quality controlled, characterized and cryopreserved batch. The differentiated β cells have applications in developmental and disease modeling, drug screening, and cell-replacement therapies. Our SCIslets can be assayed in planar and organoid culture formats. Our technology is supported by multiple publications in highly visible and rigorously peer-reviewed journals.
Our SCIslets are provided in different formats to accommodate our customers needs. We provide SCIslets in a single-cell cryopreserved format and as reaggregated clusters.
Our SCIslets are provided in different formats to accommodate our customers needs. We provide SCIslets in a single-cell cryopreserved format and as reaggregated clusters.
SCIslets-1A
Our SCislets are differentiated using hPSC's. These islets undergo glucose stimulated insulin secretion and each batch is characterized by flow cytometry and GSIS. Islets generated using our differentiation system have been used for in vitro perifusion studies, secretogogue evaluation, stress test, animal transplantation, immunoprotective device validation, compound screening, and disease modeling.
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SCIslets are provided in different formats to accommodate our customers needs. We provide SCIslets in a single-cell cryopreserved format and as organoids.
We are happy to support our customers and provide an initial free consultation regarding our product and your application of it.
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Genetic Background: Female with no history of diabetes.
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Contact us at sales@salentrabio.com for inquiries and purchases
An early access product.
SCIslet Culture Media
SKU:SCIME001
$40 per 100ml
SCIslets-Bespoke
A customizable early access product.
At Salentra we are experts in stem cell technologies and their differentiation towards SCIslets. Our state-of-the-art proprietary protocol allows for the rapid and efficient differentiation of SCIslets in a variety of genetic backgrounds. SCIslet-Bespoke are generated using a customer provided hPSC, including reporter cell lines.
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SCIslets-Bespoke
Contact sales@salentrabio.com for further information and purchase inquiries
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SCIslets are Functional
SCIslets Undergo Dynamic Insulin Secretion
Transplanted SCIslets Rapidly Cure Diabetes in Mice
SCIslets​
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Islets express endocrine hormone insulin, glucagon, and somatostatin
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Islets show protein expression of Insulin/C-Peptide, NKX6.1, PDX1, CHGA
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Islets undergo glucose simulated insulin secretion
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Islets provide reproducible data
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Applications
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Disease modeling
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Compound Screening
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Transplantation efficacy studies
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Islet function assays
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Effect and toxicology assessments
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Dose response curves
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Immune interactions
SCIslets​
​
-
Islets express endocrine hormone insulin, glucagon, and somatostatin
-
Islets show protein expression of Insulin/C-Peptide, NKX6.1, PDX1, CHGA
-
Islets undergo glucose simulated insulin secretion
-
Islets provide reproducible data
​​
Applications
-
Disease modeling
-
Compound Screening
-
Transplantation efficacy studies
-
Islet function assays
-
Effect and toxicology assessments
-
Dose response curves
-
Immune interactions